Immunogenic and isotype‐specific responses to russian and US cold‐adapted influenza a vaccine donor strains A/Leningrad/134/17/57, A/Leningrad/134/47/57, and A/Ann Arbor/6/60 (H2N2) in mice
Identifieur interne : 001872 ( Main/Exploration ); précédent : 001871; suivant : 001873Immunogenic and isotype‐specific responses to russian and US cold‐adapted influenza a vaccine donor strains A/Leningrad/134/17/57, A/Leningrad/134/47/57, and A/Ann Arbor/6/60 (H2N2) in mice
Auteurs : M. D. Wareing [Australie] ; J. M. Watson [Australie] ; M. J. Brooks [Australie] ; G. A. Tannock [Australie]Source :
- Journal of Medical Virology [ 0146-6615 ] ; 2001-09.
Descripteurs français
- KwdFr :
- Adaptation physiologique, Animaux, Anticorps antiviraux (analyse), Basse température, Cellules productrices d'anticorps (cytologie), Cellules productrices d'anticorps (immunologie), Grippe humaine (), Grippe humaine (immunologie), Humains, Isotypes des immunoglobulines (analyse), Mâle, Noeuds lymphatiques (immunologie), Poumon (immunologie), Souris, Souris de lignée BALB C, Sous-type H2N2 du virus de la grippe A, Vaccination, Vaccins antigrippaux (administration et posologie), Vaccins antigrippaux (immunologie), Virus de la grippe A (immunologie), Virus recombinants (immunologie).
- MESH :
- administration et posologie : Vaccins antigrippaux.
- analyse : Anticorps antiviraux, Isotypes des immunoglobulines.
- cytologie : Cellules productrices d'anticorps.
- immunologie : Cellules productrices d'anticorps, Grippe humaine, Noeuds lymphatiques, Poumon, Vaccins antigrippaux, Virus de la grippe A, Virus recombinants.
- Adaptation physiologique, Animaux, Basse température, Grippe humaine, Humains, Mâle, Souris, Souris de lignée BALB C, Sous-type H2N2 du virus de la grippe A, Vaccination.
English descriptors
- KwdEn :
- Adaptation, Physiological, Animals, Antibodies, Viral (analysis), Antibody-Producing Cells (cytology), Antibody-Producing Cells (immunology), Cold Temperature, Humans, Immunoglobulin Isotypes (analysis), Influenza A Virus, H2N2 Subtype, Influenza A virus (immunology), Influenza Vaccines (administration & dosage), Influenza Vaccines (immunology), Influenza, Human (immunology), Influenza, Human (prevention & control), Lung (immunology), Lymph Nodes (immunology), Male, Mice, Mice, Inbred BALB C, Reassortant Viruses (immunology), Vaccination.
- MESH :
- chemical , administration & dosage : Influenza Vaccines.
- chemical , analysis : Antibodies, Viral, Immunoglobulin Isotypes.
- cytology : Antibody-Producing Cells.
- immunology : Antibody-Producing Cells, Influenza A virus, Influenza Vaccines, Influenza, Human, Lung, Lymph Nodes, Reassortant Viruses.
- prevention & control : Influenza, Human.
- Teeft :
- Adaptation, Physiological, Allantoic virus, Animals, Antibody, Antibody production, Antibody secreting cell responses, Antibody secreting cells, Assay, Attenuated, Attenuated vaccines, Cell response, Challenge virus, Cold Temperature, Control mice, Donor, Donor strain, Donor strains, Dos, Elispot assay, Environmental biology, Genetic mutations, Higher levels, Higher numbers, Humans, Identical doses, Igg2a, Igg2a antibody secreting cell levels, Igg2a antibody secreting cells, Immune responses, Immunogenic, Immunogenicity, Immunoglobulin, Immunoglobulin responses, Individual lung extracts, Individual mice, Influenza A Virus, H2N2 Subtype, Inoculated intranasally, Inoculation, Internal genes, Intranasal inoculation, Kendal, Less immunogenic, Lung extracts, Lymph, Lymphoid tissue, Male, Mediastinal, Mediastinal lymph nodes, Mice, Mice immunised, Mice, Inbred BALB C, More immunogenic, Mouse, Node, Normal allantoic, Other countries, Parental, Parental strains, Parental virus, Parental viruses, Plaque assay, Present study, Protective dose, Reassortant, Reassortant vaccines, Reassortant viruses, Regression analysis, Relative immunogenicity, Results support, Rmit university, Second dose, Secreting, Sequence changes, Single dose, Standard challenge, Subclass responses, Tannock, Unpublished observations, Vaccination, Vaccine, Virol, Virol justewicz, Virus, Virus challenge, Virus haemagglutinin, Virus infection, Virus vaccine, Virus yields.
Abstract
The immunogenicity of the Russian cold‐adapted (ca) donor stains, A/Leningrad (Len)/134/17/57 and A/Leningrad/134/47/57, and the US strain A/Ann Arbor (AA)/6/60‐ca, were compared in BALB/c mice with their respective wild‐type parental viruses. Each ca donor strain was less immunogenic than its wild‐type parent. The vaccinating dose, when administered twice, which prevented multiplication of a standard challenge of parental wild‐type virus in 50% of mice (the 50% protective dose or PD50), was shown for A/Len/134/17/57‐ca, A/Len/134/47/57‐ca, and A/AA/6/60‐ca to be 103.77, 104.32, and 104.70, respectively. These findings were extended by measuring the number of antibody secreting cells induced in the lungs and mediastinal lymph nodes of mice infected with the same ca donors using an ELISPOT assay. When each donor strain was administered twice at a dose of 100 PD50 over a 3‐week interval, the overall immunoglobulin isotype antibody secreting cell profiles were shown to be similar. However, A/Len/134/17/57‐ca and A/Len/134/47/57‐ca induced significantly higher total immunoglobulin responses in the lungs than A/AA/6/60‐ca (P < 0.05). A/Len/134/17/57‐ca also induced a significantly greater IgA response in the lungs than A/AA/6/60‐ca (P < 0.05). These results suggest that A/Len/134/17/57‐ca is a superior immunogen to A/Len/134/47/57‐ca which in turn is more immunogenic than A/AA/6/60‐ca. J. Med. Virol. 65:171–177, 2001. © 2001 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/jmv.2017
Affiliations:
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<term>Antibodies, Viral (analysis)</term>
<term>Antibody-Producing Cells (cytology)</term>
<term>Antibody-Producing Cells (immunology)</term>
<term>Cold Temperature</term>
<term>Humans</term>
<term>Immunoglobulin Isotypes (analysis)</term>
<term>Influenza A Virus, H2N2 Subtype</term>
<term>Influenza A virus (immunology)</term>
<term>Influenza Vaccines (administration & dosage)</term>
<term>Influenza Vaccines (immunology)</term>
<term>Influenza, Human (immunology)</term>
<term>Influenza, Human (prevention & control)</term>
<term>Lung (immunology)</term>
<term>Lymph Nodes (immunology)</term>
<term>Male</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Reassortant Viruses (immunology)</term>
<term>Vaccination</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adaptation physiologique</term>
<term>Animaux</term>
<term>Anticorps antiviraux (analyse)</term>
<term>Basse température</term>
<term>Cellules productrices d'anticorps (cytologie)</term>
<term>Cellules productrices d'anticorps (immunologie)</term>
<term>Grippe humaine ()</term>
<term>Grippe humaine (immunologie)</term>
<term>Humains</term>
<term>Isotypes des immunoglobulines (analyse)</term>
<term>Mâle</term>
<term>Noeuds lymphatiques (immunologie)</term>
<term>Poumon (immunologie)</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Sous-type H2N2 du virus de la grippe A</term>
<term>Vaccination</term>
<term>Vaccins antigrippaux (administration et posologie)</term>
<term>Vaccins antigrippaux (immunologie)</term>
<term>Virus de la grippe A (immunologie)</term>
<term>Virus recombinants (immunologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Influenza Vaccines</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antibodies, Viral</term>
<term>Immunoglobulin Isotypes</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Vaccins antigrippaux</term>
</keywords>
<keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Anticorps antiviraux</term>
<term>Isotypes des immunoglobulines</term>
</keywords>
<keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Cellules productrices d'anticorps</term>
</keywords>
<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Antibody-Producing Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Cellules productrices d'anticorps</term>
<term>Grippe humaine</term>
<term>Noeuds lymphatiques</term>
<term>Poumon</term>
<term>Vaccins antigrippaux</term>
<term>Virus de la grippe A</term>
<term>Virus recombinants</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Antibody-Producing Cells</term>
<term>Influenza A virus</term>
<term>Influenza Vaccines</term>
<term>Influenza, Human</term>
<term>Lung</term>
<term>Lymph Nodes</term>
<term>Reassortant Viruses</term>
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<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en"><term>Adaptation, Physiological</term>
<term>Allantoic virus</term>
<term>Animals</term>
<term>Antibody</term>
<term>Antibody production</term>
<term>Antibody secreting cell responses</term>
<term>Antibody secreting cells</term>
<term>Assay</term>
<term>Attenuated</term>
<term>Attenuated vaccines</term>
<term>Cell response</term>
<term>Challenge virus</term>
<term>Cold Temperature</term>
<term>Control mice</term>
<term>Donor</term>
<term>Donor strain</term>
<term>Donor strains</term>
<term>Dos</term>
<term>Elispot assay</term>
<term>Environmental biology</term>
<term>Genetic mutations</term>
<term>Higher levels</term>
<term>Higher numbers</term>
<term>Humans</term>
<term>Identical doses</term>
<term>Igg2a</term>
<term>Igg2a antibody secreting cell levels</term>
<term>Igg2a antibody secreting cells</term>
<term>Immune responses</term>
<term>Immunogenic</term>
<term>Immunogenicity</term>
<term>Immunoglobulin</term>
<term>Immunoglobulin responses</term>
<term>Individual lung extracts</term>
<term>Individual mice</term>
<term>Influenza A Virus, H2N2 Subtype</term>
<term>Inoculated intranasally</term>
<term>Inoculation</term>
<term>Internal genes</term>
<term>Intranasal inoculation</term>
<term>Kendal</term>
<term>Less immunogenic</term>
<term>Lung extracts</term>
<term>Lymph</term>
<term>Lymphoid tissue</term>
<term>Male</term>
<term>Mediastinal</term>
<term>Mediastinal lymph nodes</term>
<term>Mice</term>
<term>Mice immunised</term>
<term>Mice, Inbred BALB C</term>
<term>More immunogenic</term>
<term>Mouse</term>
<term>Node</term>
<term>Normal allantoic</term>
<term>Other countries</term>
<term>Parental</term>
<term>Parental strains</term>
<term>Parental virus</term>
<term>Parental viruses</term>
<term>Plaque assay</term>
<term>Present study</term>
<term>Protective dose</term>
<term>Reassortant</term>
<term>Reassortant vaccines</term>
<term>Reassortant viruses</term>
<term>Regression analysis</term>
<term>Relative immunogenicity</term>
<term>Results support</term>
<term>Rmit university</term>
<term>Second dose</term>
<term>Secreting</term>
<term>Sequence changes</term>
<term>Single dose</term>
<term>Standard challenge</term>
<term>Subclass responses</term>
<term>Tannock</term>
<term>Unpublished observations</term>
<term>Vaccination</term>
<term>Vaccine</term>
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<term>Virus</term>
<term>Virus challenge</term>
<term>Virus haemagglutinin</term>
<term>Virus infection</term>
<term>Virus vaccine</term>
<term>Virus yields</term>
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<keywords scheme="MESH" xml:lang="fr"><term>Adaptation physiologique</term>
<term>Animaux</term>
<term>Basse température</term>
<term>Grippe humaine</term>
<term>Humains</term>
<term>Mâle</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Sous-type H2N2 du virus de la grippe A</term>
<term>Vaccination</term>
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<front><div type="abstract" xml:lang="en">The immunogenicity of the Russian cold‐adapted (ca) donor stains, A/Leningrad (Len)/134/17/57 and A/Leningrad/134/47/57, and the US strain A/Ann Arbor (AA)/6/60‐ca, were compared in BALB/c mice with their respective wild‐type parental viruses. Each ca donor strain was less immunogenic than its wild‐type parent. The vaccinating dose, when administered twice, which prevented multiplication of a standard challenge of parental wild‐type virus in 50% of mice (the 50% protective dose or PD50), was shown for A/Len/134/17/57‐ca, A/Len/134/47/57‐ca, and A/AA/6/60‐ca to be 103.77, 104.32, and 104.70, respectively. These findings were extended by measuring the number of antibody secreting cells induced in the lungs and mediastinal lymph nodes of mice infected with the same ca donors using an ELISPOT assay. When each donor strain was administered twice at a dose of 100 PD50 over a 3‐week interval, the overall immunoglobulin isotype antibody secreting cell profiles were shown to be similar. However, A/Len/134/17/57‐ca and A/Len/134/47/57‐ca induced significantly higher total immunoglobulin responses in the lungs than A/AA/6/60‐ca (P < 0.05). A/Len/134/17/57‐ca also induced a significantly greater IgA response in the lungs than A/AA/6/60‐ca (P < 0.05). These results suggest that A/Len/134/17/57‐ca is a superior immunogen to A/Len/134/47/57‐ca which in turn is more immunogenic than A/AA/6/60‐ca. J. Med. Virol. 65:171–177, 2001. © 2001 Wiley‐Liss, Inc.</div>
</front>
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<name sortKey="Tannock, G A" sort="Tannock, G A" uniqKey="Tannock G" first="G. A." last="Tannock">G. A. Tannock</name>
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